Yes, but 2-piece syringes maintain foam stability better. If using a 3-piece syringe, you should choose an appropriate brand and bear in mind that STS foam is much less stable and greatly affected by silicone content. In this situation, 5 mL syringes perform better than 10 mL syringes.
It must be taken into account that the 2 and 5 mL 3-piece syringes have little friction, so when the sclerosant is introduced into the VARIXIO Pod Air capsule, its plunger may go back (due to the overpressure generated inside the capsule) can cause the unintentional aspiration (back into the syringe) of up to 0.5 mL of sclerosant, that is, 25% of the capsule load. This circumstance could affect the quality and volume of foam manufactured. In no case would it affect the safety of the patient.
To avoid this effect when using 3-piece syringes of 2, 5 or 10 mL, we suggest considering the following alternative use: Open the upper cap before introducing the sclerosant into the capsule.